1566 April 19, POPE PIUS V (The Papal States, Italy)
Three months into his reign, he rejected the leniencies of his predecessor and re-invoked all the restrictions of Paul IV. These included Jews being forced to wear a special cap as well as the prohibitions against owning real estate ( see 1567) and practicing medicine on Christians. Communities were not allowed to have more than one synagogue and Jews were confined to a cramped ghetto.
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